pentobarbital increases toxicity of buprenorphine, extended-acting injection by pharmacodynamic synergism. Modify Therapy/Keep track of Carefully. Coadministration of buprenorphine and benzodiazepines or other CNS depressants raises risk of adverse reactions including overdose, respiratory depression, and Dying. Cessation of benzodiazepines or other CNS depressants is most popular in most cases.
pentobarbital will minimize the extent or result of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a delicate CYP3A4 substrate. Coadministration with potent or reasonable CYP3A4 inducers is contraindicated.
Remark: Barbiturates might boost adverse effects, together with respiratory despair, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and reduce blood concentrations of TCAs.
Monitor Carefully (one)pentobarbital will lessen the extent or effect of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the extent or outcome of bazedoxifene/conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will decrease the level or effect of quetiapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will minimize the level or result of flurbiprofen by influencing hepatic enzyme CYP2C9/ten metabolism. Small/Significance Mysterious.
pentobarbital will raise the stage or effect of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will reduce the level or outcome of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. If unable to avoid coadministration of stiripentol with potent CYP3A4 inducers, raise stiripentol dose.
pentobarbital will minimize the extent or impact of etoposide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will lessen the extent or effect of tamoxifen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.
Much too immediate administration may possibly result in respiratory depression, laryngospasm, click here apnea, or vasodilation with tumble in blood pressure level
pentobarbital will decrease the level or outcome of alosetron by impacting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Importance Unfamiliar.